CAS:
30562-34-6
Molecular
Formula: C29H40N2O9
Molecular
weight:560.6359
Geldanamycin
is a benzoquinone antineoplastic antibacterial abandoned from the bacillus
Streptomyces hygroscopicus. Geldanamycin binds to and inhibits the cytosolic
babysitter functions of calefaction shock protein 90 (HSP90). HSP90 maintains
the adherence and anatomic appearance of abounding oncogenic signaling
proteins; the inhibition of HSP90 promotes the proteasomal abasement of
oncogenic signaling proteins that may be over-expressed or overactive in bump
cells.
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