Imiquimod Mechanism of Action

Imiquimod is a toll-like receptor-7 agonist acceptable both the congenital and acquired allowed response.It activates the assembly of abundant compounds, including IFN-α, IL-1, -6, -8, -10, -12, and TNF-α, stimulates accustomed analgesic beef and the admeasurement of B-cells. It aswell activates Langerhans cells, the key antigen-presenting corpuscle in the skin, and promotes their clearing to the bounded lymph nodes. Imiquimod stimulates TH-1 beef to aftermath IFN-γ, which in about-face can actuate cytotoxic T lymphocytes. These beef accommodate abiding allowed memory, which can action approaching aegis adjoin the ahead encountered virus or tumor. In beastly models, imiquimod use can authorize abiding amnesty adjoin bacilli and assertive tumors.

Recently, imiquimod has been crystalline to advance the announcement of cellular receptors that are associated with apoptosis.There is ascent affirmation that imiquimod antitumor action in vivo stems from the aftereffect it has on the congenital and cell-mediated allowed response, including corpuscle crystalline markers.