CAS
No.: 80576-83-6
Molecular
Formula:C22H25N7O5
Molecular
Weight: 467.48
Edatrexate
is a polyglutamatable folate adversary alternation of methotrexate with
antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby
accretion cellular levels of polyglutamates, inhibiting thymidylate synthase
and glycinamide ribonucleotide formyl transferase, impairing amalgam of purine
nucleotides and amino acids, and consistent in bump corpuscle death. Edatrexate
may affected bump attrition to methotrexate, which loses its action afterwards
it is polyglutamated.
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