What is Lonidamine?

CAS No.:50264-69-2

Molecular Formula:C15H10Cl2N2O2

Molecular Weight:321.16

Lonidamine is a acquired of indazole-3-carboxylic acid, which for a continued time, has been accepted to arrest aerobic glycolysis in blight cells. It seems to enhance aerobic glycolysis in accustomed cells, but abolish glycolysis in blight cells. This is a lot of acceptable through the inhibition of the mitochondrially apprenticed hexokinase. Later studies in Ehrlich ascites bump beef showed that lonidamine inhibits both respiration and glycolysis arch to a abatement in cellular ATP.

Clinical trials of lonidamine in aggregate with added anticancer agents for a array of cancers has begun. This is due to its accurate adeptness to arrest action metabolism in blight cells, and to enhance the action of anticancer agents.

Lonidamine has been used in the analysis of academician tumours in aggregate with radiotherapy and temozolomide. An in-vitro extraction showed that a aggregate of temozolomide and lonidamine at clinically achievable, low blood concentrations, could arrest tumour growth, and lonidamine could abate the dosage of temozolomide appropriate for radiosensitization of academician tumours.

A acquired of lonidamine, gamendazole, is in testing as a accessible macho contraceptive pill.