Trazodone Interactions

Because both trazodone and associates of the chic of antidepressants accepted as monoamine oxidase (MAO) inhibitors may access serotonin levels in the brain, the aggregate of these drugs can growth to a action accepted as serotonin syndrome. Symptoms of serotonin affection cover a abiding accelerated affection rate, hypertension (high claret pressure), bloom of the skin, hallucinations , tremors, and hyperthermia (increased physique temperature). Because of this, it can be alarming to yield trazodone in aggregate with MAO inhibitors such as Nardil ( phenelzine sulfate) or Parmate ( tranylcypromine sulfate). The aforementioned holds accurate if accumulation trazodone with a careful serotonin uptake inhibitor (SSRI) antidepressant such as Prozac (fluoxetine), paroxetine, or sertraline.

Trazodone may access the claret pressure–lowering furnishings in patients who are demography antihypertensive medications. Patients who yield these drugs calm should accept their claret burden monitored consistently so that their antihypertensive medications can be adapted if their claret burden becomes too low.

The allaying furnishings of trazodone are added by added axial afraid arrangement depressants such as alcohol, sedatives, sleeping medications, or medications used for added brainy disorders such as schizophrenia . The anticholinergic furnishings of trazodone may be accretion with added anticholinergic drugs such as benztropine , biperiden , trihexyphenidyl , and antihistamines.