Synonym: Paraderil; Dactinol; Rotocide
CAS Number: 83-79-4
Purity: ≥98%
Molecular Weight: 394.42
Molecular Formula: C23H22O6
Solubility: Soluble in ethanol (1:300), chloroform (1:3), ether (1:200), and DMSO (100 mM). Insoluble in water.
Melting Point: 159-164° C
Boiling Point: 210-220° C at 0.5 mmHg
Density: 1.27 g/cm3 at 20° C
Application: A mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I of the respiratory chain
Storage: Store at room temperature
Description:
Rotenone is a mitochondrial electron carriage inhibitor, which accurately inhibits NAD-linked substrate blaze of NADH dehydrogenase with an EC50=10 pmol/mg. It is accepted that this arrest of the electron carriage alternation occurs from circuitous I to ubiquinone, analogously to amytal. Studies announce that Rotenone inhibits beastly corpuscle proliferation, via suppressing microtubule accumulation by bounden to tubulin. Rotenone can arrest the furnishings of N-methyl-4-phenylpyridinium on mitochondrial abscess and cytochrome c release. Rotenone is an inhibitor of NDUFS.
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